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. 2016 Jan 8;9:165. doi: 10.3389/fnsys.2015.00165

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Copyright © 2016 Mingote, Masson, Gellman, Thomsen, Lin, Merker, Gaisler-Salomon, Wang, Ernst, Hen and Rayport.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Attenuation of amphetamine-induced hyperlocomotion in Tmx-Treated GLS1 iHet mice. (A) Amphetamine-induced locomotion. Tmx-naïve (No-Tmx) mice prior to and after amphetamine (AMPH) injection showed no genotypic difference in locomotion in the open field. (B) Locomotion before and after amphetamine for Tmx-treated mice. (B1) Tmx-Treated mice showed a marked genotypic difference in amphetamine-induced hyperlocomotion, 30 days post-Tmx. Factorial ANOVA revealed a significant genotype × time effect of amphetamine (p < 0.05), but no difference prior to amphetamine. (B2) The reduction in amphetamine-induced hyperlocomotion persisted 146 days post-Tmx. (C) Total locomotion after amphetamine injection. (C1) Tmx-naïve (No-Tmx) mice showed no genotypic difference in their overall response to amphetamine, whereas Tmx-Treated control mice differed significantly from GLS1 iHET mice 30 days post-Tmx (left graph). ^*indicates a significant genotypic difference, p < 0.05. The amphetamine-induced locomotion of Tmx-Treated mice did not change 146 days post-Tmx treatment. ^##indicates a main effect of genotype, p < 0.001; but no main effect of time or significant interaction. (C2) AMPH-induced hyperlocomotion expressed as an increase in locomotion above baseline. Tmx-Treated GLS1 iHET mice showed a minimal response to amphetamine at 30 days post-Tmx (5% increase in locomotion in response to AMPH), and a modest response at 146 days (25%).