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. 2016 Jan 8;5:294. doi: 10.3389/fonc.2015.00294

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Copyright © 2016 Simoniello, Wiedemann, Zink, Thoennes, Stange, Layer, Kovacs, Podda, Durante and Fournier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proliferation activity measured by Ki67 staining in HSE and human skin explants after irradiation with X-ray and carbon ions. (A) Ki67-positive cells (arrows) in the basal layer of HSE. (B) Number of Ki67-positive cells in the HSE, normalized on the total number of cells in the basal layer and shown relative to the controls, shows enhanced proliferation after 0.5 Gy X-ray irradiation. (C) Ki67-positive cells in human skin explants (arrows); quantification shows an increase of proliferation after low dose of X-rays; N = 2, n = 4.