Figure 5.

Changed polarity of basal cells in HSE after irradiation with X-ray and carbon ions. (A) Transition of palisade-like morphology of basal cells to a cobblestoned morphology indicating a change in polarity and disorganization of the basal layer. (B) Quantification of palisade-like morphology and cobblestoned (partial or total) morphology shows a transition for all doses of X-ray and carbon ions; most pronounced and highly significant for 0.5 Gy. (C) E-Cadherin staining shows a delocalization of the protein in the cells from the basal layer (arrows) 72 h after irradiation with 0.5 Gy X-rays; SEM; *p ≤ 0.05, **p ≤ 0.01; ***p ≤ 0.001; N = 2, n = 4.