Figure 1.

Schematic representation of the protein pathology contribution to neurodegenerative disease via chronic Endoplasmic Reticulum (ER) stress. Misfolded proteins aggregate and form prominent inclusions as the characteristic pathological hallmark of these disorders. ER stress results from the accumulation of misfolded proteins within the ER, thus activating the Unfolded Protein Response (UPR), which if prolonged or unresolved, can result in neuronal cell death, and hence neurodegenerative disorders.