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The structure of Protein Disulfide Isomerase (PDI). PDI has four distinct domains, a, a', b, and b', as well as a linker region, “x”, and its C-terminal extension with KDEL sequence. The catalytic domains, a and a', possess active sites containing the motif cysteine-glycine-histidine-cysteine (CGHC). KDEL, the ER retention signal sequence.
