Table 6.
Pharmacokinetics parameters of seven analytes after an oral administration (n = 6).
| Compounds | AUC0−t (ng/ml/h) | Cmax (ng/ml) | Tmax (h) | T1/2 (h) | CL (ml/h) |
|---|---|---|---|---|---|
| Quercetin | |||||
| Ginaton | 28.47 ± 10.44 | 3.81 ± 2.35 | 0.31 ± 0.07 | 8.81 ± 0.29 | 12720.04 ± 4198.09 |
| GbP | 112.41 ± 34.32$ | 16.78 ± 5.08$ | 0.47 ± 0.07# | 10.52 ± 2.26 | 3012.87 ± 740.40$ |
| Kaempferol | |||||
| Ginaton | 310.07 ± 92.96 | 23.65 ± 8.95 | 6.33 ± 0.82 | 10.04 ± 1.28 | 621.73 ± 192.20 |
| GbP | 976.87 ± 138.15$ | 60.13 ± 9.56$ | 8.00 ± 1.26⁎ | 12.68 ± 1.51# | 161.40 ± 13.86$ |
| Isorhamnetin | |||||
| Ginaton | 106.72 ± 33.44 | 8.41 ± 2.60 | 5.67 ± 0.82 | 7.71 ± 0.68 | 1235.96 ± 378.93 |
| GbP | 566.59 ± 156.33$ | 37.51 ± 11.75$ | 7.67 ± 0.82# | 12.96 ± 1.90$ | 176.70 ± 35.62$ |
| Bilobalide | |||||
| Ginaton | 384.58 ± 93.57 | 102.99 ± 15.51 | 1.17 ± 0.41 | 2.35 ± 0.72 | 612.04 ± 156.76 |
| GbP | 406.83 ± 43.23 | 103.97 ± 15.26 | 1.83 ± 0.41⁎ | 2.72 ± 1.30 | 560.09 ± 61.94 |
| Ginkgolide A | |||||
| Ginaton | 166.34 ± 20.69 | 53.42 ± 18.83 | 1.00 ± 0.00 | 1.61 ± 0.14 | 1117.64 ± 138.65 |
| GbP | 618.80 ± 110.07$ | 173.97 ± 5.68$ | 1.00 ± 0.00 | 5.74 ± 0.78$ | 304.71 ± 54.59$ |
| Ginkgolide B | |||||
| Ginaton | 74.42 ± 8.58 | 19.80 ± 6.98 | 1.50 ± 0.55 | 2.38 ± 0.61 | 1509.77 ± 169.71 |
| GbP | 461.24 ± 173.57$ | 96.98 ± 32.94$ | 1.67 ± 0.52 | 8.85 ± 0.62$ | 262.57 ± 102.28$ |
| Ginkgolide C | |||||
| Ginaton | 31.70 ± 6.76 | 5.68 ± 1.84 | 1.00 ± 0.00 | 5.81 ± 1.08 | 2569.97 ± 506.86 |
| GbP | 99.35 ± 19.56$ | 13.32 ± 3.76# | 2.67 ± 1.03# | 9.08 ± 0.82$ | 909.29 ± 185.36$ |
⁎
Difference from corresponding Ginaton group, P < 0.05.
#
Difference from corresponding Ginaton group, P < 0.01.
$
Difference from corresponding Ginaton group, P < 0.001.