FIGURE 1.

Heliobacter typhlonius genomic architecture. Circos plot outlines the genomic features of H. typhlonius. On the outside, sites with short tandem repeats are indicated by black dots. The following ring (outside to inside) illustrates protein-encoding genes for the forward and reverse strand, colored by associated subsystem. Delineated separately (inner spots) are multiple pathogenic features, including cytolethal distending toxins (black), components of the T4SS (blue), virulence-associated protein 2 s (purple), a Cag pathogenicity island protein (red) and sequences that match pathogenic protein families in H. hepaticus (gray). The overall GC content is shown in blue, where light blue regions indicate <5% and dark blue >5% deviation from the average GC content (bin size: 1 Kb). The coverage profile of the SMRT sequencing reads is shown in gray (bin size: 1 Kb). On the inside, repetitive sequences and structural variations (>95% similarity at the nucleotide level) are shown throughout the genome with repeats >6 Kb colored red.