FIGURE 4.
Stimulation of GPR17 predominantly triggered Gαi/o signaling in oligodendroglial cells. Characteristic DMR traces triggered by MDL29,951 in Oli-neu cells pretreated for 24 h with 1 μm PD174265 (A) and primary rat differentiating oligodendrocytes after culturing for 48 h in growth factor-free medium (B) in the presence or absence of PTX. Shown are concentration-response curves generated from the traces of seven independent experiments in Oli-neu cells (C) and six different experiments in oligodendrocytes (D).