TABLE 1.

Plasma biochemistry

Five-month-old male mice (n ≥13 for all parameters, except for n ≥4 for GLP-1) were fasted overnight before retro-orbital blood was drawn, and plasma levels of hormones were assayed. To determine basal glucagon level, mice were fasted for 4 h before their retro-orbital blood was drawn. Data are means ± S.E.

	Cc2+/+	Cc2−/−
Body weight (g)	25.7 ± 0.34	26.0 ± 0.65
Insulin (pm)	57.3 ± 4.19	63.0 ± 5.77
C-peptide (pm)	349. ± 38.3	670. ± 91.5a
C/I ratio (steady state)	5.98 ± 0.44	10.3 ± 0.96a
Glucagon (pg/ml)	57.9 ± 1.20	60.0 ± 1.28
Somatostatin (pg/ml)	819. ± 9.86	823. ± 16.1
GLP-1 (pm)	1.46 ± 0.15	4.81 ± 1.23a

^a p < 0.05 versus Cc2^+/+.