Table 3.
Summary of metabolomic studies of hepatitis B virus-related hepatocellular carcinoma
| Ref. | Year | Species | Tissue | Platform | Up-regulated | Down-regulated |
| Li et al[56] | 2015 | Human | Liver | NMR | Fructose-bisphosphatealdolase, glucose-6-phosphate isomerase, alpha-enolase, citrate synthase | 4-hydroxyphenylpyruvate dioxygenase |
| Hepatoblastoma cell line | Host cell | Phosphoglycerate kinase 1 | Fumarylacetoacetase | |||
| HepG2.2.15/HepG2 | Triosephosphate isomerase | |||||
| Sussinate dehydrogenase | ||||||
| Malate dehydrogenase | ||||||
| Liu et al[52] | 2013 | Human | Liver | UPLC-MS | Sitosterol-beta, L-phenylalanine, LysoPC [18:2 (9Z, 12Z)], quinaldic acid glycerophosphocholine, LysoPC (18:0) | Arachidyl carnitine |
| HCC 10 | LysoPE (18:0/0:0), chenodeoxycholic acid glycine conjugate | Tetradecanal | ||||
| Central/distant | LysoPE [18:3 (9Z, 12Z, 15Z)/0:0] | Oleamide | ||||
| LysoPC [22:6 (4Z, 7Z, 10Z, 13Z, 16Z, 19Z)] M | ||||||
| LysoPC [20:4 (5Z, 8Z, 11Z, 14Z)] | ||||||
| Zhou et al[23] | 2012 | Human | Serum | LC-MS | GCA, GCDCA, C16:1-CN | Tryptophan, C10:1-CN, C8-CN, C10-CN, |
| HCC 30 N 30 | C6-CN, LysoPC (20:5) | |||||
| HCC/N | LysoPC (0:0/14:0), LysoPC (20:3), LysoPC (14:0/0:0) | |||||
| Yin et al[41] | 2009 | Human | Serum | LC-MS | Taurocholic acid, GCA, bilirubin, TCDCA, GCDCA, oleic acid, taurocholic acid, carnitine, L-acetylcarnitine | Hypoxanthine, phytosphingosine, dihydrosphingosine, LPC C18:2, LPC C18:3, LPC C16:1, LPC C18:0 phytosphingosine, inosine, hypoxanthine, taurine, 6-methylnicotinic acid |
| HCC 24 N 25 | ||||||
| HCC/N |
LC-MS: Liquid chromatography-mass spectrometry; LysoPC: Lysophosphatidylcholine; LysoPE: Lysophosphatidylethanolamine; LPC: Lysophosphatidylcholine; GCA: Glycocholic acid; TCDCA: Taurochenodeoxycholic acid; GCDCA: Glycochenodeoxycholic acid; UPLC-TOFMS: Ultra-high performance liquid chromatography-time of flight-mass spectrometer; CN: C16:1-acylcarnitine; HCC: Hepatocellular carcinoma.