Table 4.

Combined morphological/biological selection criteria

Ref.	Parameters	Importance
DuBay et al[60]	Liver tumor biopsy	Excluding poorly differentiated tumors
Toso et al[52]	TTV > 115 cm3	Reduced survival at 3 yr (< 50%)
	AFP > 400 ng/mL	Limit for indication for LT
Lai et al[62]	AFP > 400 ng/mL	Strongest predictor for recurrence
	Total tumor diameter > 8 cm
Duvoux et al[63]	Model combining log10 AFP, tumor size and n of tumors: Score > or < 2	Score greater that 2 predict a market increase in 5 yr risk of recurrence and decreased survival
Berry et al[66]	AFP < 15 or > 15 ng/mL	AFP levels predicts post-transplant survival independently of MC

TTV: Total tumor volume; AFP: Alpha fetoprotein; MC: Milan criteria; LT: Liver transplantation.