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. 2016 Jan 8;6:18809. doi: 10.1038/srep18809

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(A) Validation of the in situ DNaseI-sensitivity assay: MGF-C25E reduces the rate of digestion. Photomicrographs show that the nuclear sizes of the MGF-C25E-treated cells are significantly increased when compared to those of the control cells. The inhibition of the FAK or ERK1/2 signals repressed the MGF-C25E-induced increase in the nuclear size. Bars = 100 μm. (B) Quantitative analysis of the mean size of nuclei after DNaseI as shown in A. Data are expressed as the means ± SD; n = 3 in each group; *p < 0.05 and **p < 0.01.