. 2016 Jan 8;6:19083. doi: 10.1038/srep19083

Table 1. Relative abundances of phyla and genera changed by diet intervention (%, means ± SEM).

Phase 1 diet (wks 3 to 21)	Control (C)			High-fat (H)			Energy restriction (E)			p
Phase 2 diet (wks 22 to 60)	C	H	E	C	H	E	C	H	E	p
Bacteroidetes	43.7 ± 3.6^a	43.4 ± 3.5^a	30.9 ± 2.0^a	29.4 ± 5.7^a	32.7 ± 4.9^a	32.3 ± 2.9^a	44.4 ± 4.1^a	45.9 ± 4.7^a	39.0 ± 2.0^a	0.0007
Bacteroidia
Prevotella	1.2 ± 1.0^a	7 ± 0.9^b	0.5 ± 0.6^a	0.2 ± 1.6^a	0.5 ± 1.3^a	0.6 ± 0.8^a	0.8 ± 1.1^a	3 ± 1.3^ab	1.1 ± 0.6^a	<0.0001
Unknown genus in Rikenellaceae	14 ± 1.1^a	13 ± 1.0^a	4.1 ± 0.6^b	5.9 ± 1.7^bc	12 ± 1.5^ac	5 ± 0.9^b	10 ± 1.2^ac	13 ± 1.4^ac	6 ± 0.6^b	<0.0001
Unknown genus in S24-7	4.5 ± 0.7^ac	1.3 ± 0.7^a	2.6 ± 0.4^ab	3.9 ± 1.1^abd	3.8 ± 0.9^bc	2.8 ± 0.5^abc	8.1 ± 0.8^d	5.5 ± 0.9^cd	3.5 ± 0.4^bc	<0.0001
Bacteroides	16 ± 2.3^ab	16 ± 2.2^ab	17 ± 1.3^ab	15 ± 3.7^ab	12 ± 3.2^b	16 ± 1.9^ab	18 ± 2.7^ab	15 ± 3.1^ab	22 ± 1.3^a	0.0107
Parabacteroides	7.2 ± 0.8^ab	5.3 ± 0.7^b	5.1 ± 0.4^ab	3.7 ± 1.2^ab	4.2 ± 1.0^ab	7.1 ± 0.6^a	6.1 ± 0.9^ab	6.9 ± 1.0^ab	5.9 ± 0.4^ab	0.0021
Deferribacteres	4.5 ± 2.2^ab	1.7 ± 2.1^b	8.8 ± 1.2^a	6.2 ± 3.5^ab	3.7 ± 3.0^ab	8.3 ± 1.8^a	2.8 ± 2.5^b	4.4 ± 2.9^ab	3.8 ± 1.3^ab	0.0031
Deferribacteres
Mucispirillum	4.5 ± 2.2^ab	1.7 ± 2.1^b	8.8 ± 1.2^a	6.2 ± 3.5^ab	3.7 ± 3.0^ab	8.3 ± 1.8^a	2.8 ± 2.5^b	4.4 ± 2.9^ab	3.8 ± 1.3^ab	0.0031
Firmicutes	47.7 ± 3.6^a	46.3 ± 3.5^a	58.0 ± 2.0^a	61.1 ± 5.8^a	62.2 ± 5.0^a	56.7 ± 2.9^a	46.4 ± 4.2^a	46.8 ± 4.8^a	55.4 ± 2.1^a	0.0034
Bacilli
Lactobacillus	0.4 ± 1.6^b	0.3 ± 1.5^b	7.6 ± 0.9^a	2.2 ± 2.5^b	2.1 ± 2.2^b	8 ± 1.3^a	2.1 ± 1.8^b	1.7 ± 2.1^b	8.7 ± 0.9^a	<0.0001
Clostridia
Unknown genus in Clostridiales	25 ± 2.9^abc	23 ± 2.8^c	28 ± 1.6^abc	41 ± 4.6^a	38 ± 4.0^ab	25 ± 2.3^abc	20 ± 3.3^bc	26 ± 3.8^abc	25 ± 1.6^abc	0.0022
Unknown genus in Lachnospiraceae	3.4 ± 0.8^ab	4.8 ± 0.7^ab	3.9 ± 0.4^ab	5.3 ± 1.2^ab	6.4 ± 1.1^a	4.1 ± 0.6^ab	1.8 ± 0.9^b	4.9 ± 1.0^ab	4.1 ± 0.4^ab	<0.0190
Unknown genus in Ruminococcaceae	1.8 ± 0.3^a	3.0 ± 0.3^a	2.3 ± 0.2^a	1.2 ± 0.5^a	2.8 ± 0.4^a	2.3 ± 0.3^a	1.5 ± 0.4^a	1.7 ± 0.4^a	2.1 ± 0.2^a	<0.0449
Ruminococcus	2.3 ± 0.4^abc	1.2 ± 0.4^b	2.8 ± 0.2^ac	1.0 ± 0.7^bc	0.9 ± 0.6^b	3.4 ± 0.3^a	4.2 ± 0.5^a	0.9 ± 0.5^b	1.7 ± 0.2^b	<0.0001
Erysipelotrichi
Allobaculum	2.1 ± 0.8^ac	0.6 ± 0.7^b	1.4 ± 0.4^abc	1.0 ± 1.2^abc	0.3 ± 1.1^b	0.5 ± 1.0^abc	3.8 ± 0.9^a	0.5 ± 1.0^bc	2.3 ± 0.4^abc	<0.0001
Verrucomicrobia	2.4 ± 0.5^a	2.0 ± 0.5^ab	0.6 ± 0.3^b	1.9 ± 0.8^ab	0.4 ± 0.7^b	1.3 ± 0.4^ab	3.4 ± 0.6^a	1.5 ± 0.6^ab	0.9 ± 0.3^b	<0.0001
Verrucomicrobiae
Akkermansia	2.4 ± 0.5^a	2.0 ± 0.5^ab	0.6 ± 0.3^b	1.9 ± 0.8^ab	0.4 ± 0.7^b	1.3 ± 0.4^ab	3.4 ± 0.6^a	1.5 ± 0.6^ab	0.9 ± 0.3^b	<0.0001

Different letters denote significant differences in pair-wise comparisons (p < 0.05). p-value in ANOVA for unbalanced sample with Bonferroni adjustment.