Skip to main content
. 2016 Jan 8;6:19106. doi: 10.1038/srep19106

Figure 5. Cultured hippocampal neurons from offspring of polyI:C-treated mothers exhibit no change in sEPSC charge transfer but larger charge transfer of sIPSC.

Figure 5

(A) Representative voltage-clamp recording of sEPSC of cultured hippocampal neurons from offspring of saline (left) and polyI:C (right)-injected mothers. (B) Cultured hippocampal neurons from the offspring of polyI:C treated mothers display similar sEPSC charge transfer compared to that of offspring from saline-treated mothers (Q = 99 ± 10 pA*s, n = 44 from 6 polyI:C-injected mothers Q = 103 ± 10 pA*s, n = 41 from 6 saline-injected mothers). (C) Representative voltage-clamp recording of sIPSC of cultured hippocampal neurons from offspring of saline (left) and polyI:C (right)-injected mothers. (D) Cultured hippocampal neurons from offspring of polyI:C-treated mothers exhibit larger sIPSC charge transfer compared to those from offspring of saline-treated mothers (Q = 173 ± 23 pA*s, n = 38 from 6 polyI:C-injected mothers versus Q = 112 ± 16 pA*s, n = 47 from 6 saline-injected mothers; t(83) = 2.25, p < 0.03).