Table 3.

The performance metrics of four simulation scenarios.

Scenario	Initial CPU Time (sec)	CPU Time for 100 simulation Cycles (sec)	Memory Footprint Size (MB)
Reduced model (RM)	14.35	296.81	399.1
Big model (BM)	14.17	23119.69	404.9
Multiple ODE solvers (MS)	5301.96	309.75	1480.0
Dynamic frequency (DF)	14.87	40.95	373.8

Initial CPU time is the CPU time used for the initialization of the simulation. In the RM, a reduced intracellular ODE model is utilized, where one single shared ODE solver object is used; the simulation frequencies are 1 for all scales. BM utilizes the comprehensive ODE model. MS is based on multiple ODE solver objects, one for each T cell object. DF uses reduced intracellular scale approach with simulation frequency from 1 to 0.1.