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. 2016 Jan 8;6:18995. doi: 10.1038/srep18995

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The HG cells cultured in the high glucose media (H-HG) were switched to be cultured in normal glucose media (N-HG) and compared for (A) cell proliferation; (B) expression of p-STAT3 (Y705 and S727). The numbers represent the pSTAT3 to STAT3 ratios of each band; (C) The treatment of Stattic (STAT3 inhibitor) significantly reduced proliferation and (D) inhibited nuclear translocation of STAT3 and p-STAT3 (S727) of HG cells. NG and HG = cells were continuously cultured in normal and high glucose media; *P < 0.05, ***P < 0.001.