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. 2016 Jan 8;6:19004. doi: 10.1038/srep19004

Figure 6. CPUY201112 inhibits the growth of MCF-7 xenografts in nude mice.

Figure 6

(A–C) Female nude mice implanted with MCF-7 xenografts were treated with 5 mg/kg or 10 mg/kg of CPUY201112 for 24 days. Tumor diameters were measured and used to calculate tumor volumes (A). After 24 days, the mice were sacrificed, and individual tumors were weighed (B). *p < 0.05, student t-test (n = 6). (D) Western blot analysis of Hsp70 and Akt in the tumor. *p < 0.05; **p < 0.01; Student t-test (n = 3). The blots are cropped and the gel were run under the same condition. (E) Representative H&E images of individual tumors. (F) Immunohistochemical evaluation to assess HER-2 levels in MCF-7 tumor tissue after treatment with CPUY201112.