Figure 5.
Molecular heterogeneity of AML exemplified by mutational profiling in NPM1c AML. Summary of targeted sequencing data using a published panel100 covering 14 mutational groups conducted in diagnostic samples from a cohort of 223 patients with NPM1c AML.9 Each spoke radiating from the central NPM1c hub represents the mutation pattern of a single patient. Cooperating mutations are grouped into 4 tiers according to function and color coded according to the figure key, and white space indicates no mutation. For example, in the patient displayed at 12 o’clock, mutations were detected in NPM1, DNMT3A, TET2, FLT3 (ITD), and STAG2. Overall, based on mutational combination, patients segregated into >75 different subgroups.