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. 2015 Sep 17;44(1):164–174. doi: 10.1093/nar/gkv927

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — p53 does not bind to promoters of genes harboring CHR sites. Protein binding to promoters of the indicated genes was tested by ChIP in (A) HCT116 wild-type cells, (B) HCT116 p21^−/− and (C) HFF cells either left untreated or treated with doxorubicin for 24 h (HFF) or 48 h (HCT116) followed by real-time PCR. The CDKN1A promoter served as a positive control for p53 binding; the GAPDHS promoter which does not bind p53 was used as a negative control. One representative experiment with three technical replicates (n = 3) is displayed.