Figure 1.

Transplantation of human spinal cord progenitors after dorsal root avulsion injury.

(A) Dorsal root avulsion (DRA) injury results in the disconnection of sensory axons from the spinal cord, disintegration of the dorsal root transitional zone (DRTZ) and a longitudinal spinal cord injury of the dorsal column and horn. (B) Transplantation of human spinal progenitors to the site of L_3–5 DRA contributes to the regeneration of a subset of sensory fibres by providing a growth permissive environment. Reprinted by permission from Macmillan Publishers Ltd: [Scientific Reports] (Hoeber et al., 2015), copyright (2015).