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Examples of skin toxicities experienced by patients treated with vemurafenib. A shows a patient with a maculopapular rash, which developed approximately 3 weeks after initiation of vemurafenib therapy. B shows squamous cell carcinoma of the skin, which was detected 4 to 6 weeks after initiation of vemurafenib therapy. C shows a case of hand-foot skin reaction with hyperkeratosis, which was also reported as palmar-plantar erythrodysesthesia syndrome.
