Table 3. Reduced constant multivariable Cox regression analysis for predicting 5-year CCSS over time.
|
Multivariable model as time elapsed since surgery |
||||||
|---|---|---|---|---|---|---|
| Baseline | 1 Year | 2 Year | 3 Year | 4 Year | 5 Year | |
|
Reduced Modela | ||||||
| pT (pT3+pT4 vs pT1+pT2) | ||||||
| HR | 4.35 (+0.22) | 4.03 (+0.16) | 4.40 (+0.22) | 4.29 (+0.26) | 4.76 (+0.37) | 3.86 (+0.47) |
| 95% CI | 2.10–9.02 | 2.06–7.88 | 2.27–8.52 | 2.13–8.66 | 2.07–10.94 | 1.42–10.45 |
| P-value | <0.001 (0.001) | <0.001 (0.001) | <0.001 (0.001) | <0.001 (0.001) | <0.001 (0.002) | 0.008 (0.004) |
| Fuhrman grade (3+4 vs 1+2) | ||||||
| HR | 4.11 (+0.46) | 3.49 (+0.27) | 2.72 (+0.18) | 2.53 (+0.24) | 2.32 (+0.22) | 2.08 (+0.21) |
| 95% CI | 1.98–8.53 | 1.79–6.80 | 1.42–5.25 | 1.26–5.07 | 1.04–5.21 | 0.73–5.95 |
| P-value | <0.001 (0.001) | <0.001 (0.001) | 0.003 (0.001) | 0.009 (0.018) | 0.041 (0.041) | 0.171 (0.173) |
| MVI (present vs absent) | ||||||
| HR | 2.20 (+0.05) | 2.04 (+0.07) | 1.83 (+0.07) | 2.16 (+0.12) | 2.34 (+0.12) | 1.21 (+0.01) |
| 95% CI | 1.05–4.62 | 1.02–4.08 | 0.90–3.72 | 1.04–4.48 | 0.99–5.52 | 0.334–4.40 |
| P-value | 0.037 (0.025) | 0.044 (0.047) | 0.095 (0.095) | 0.038 (0.051) | 0.052 (0.060) | 0.770 (0.734) |
| Sarcomatoid features (presented vs none) | ||||||
| HR | 4.10 (−0.75) | 4.32 (−0.24) | 3.57 (−0.57) | 4.06 (−0.90) | 3.72 (−2.71) | 4.36 (−3.34) |
| 95% CI | 1.24–13.59 | 1.44–12.91 | 1.09–11.76 | 1.18–14.00 | 0.70–19.79 | 0.74–25.82 |
| P-value | 0.021 (0.010) | 0.009 (0.013) | 0.036 (0.050) | 0.026 (0.043) | 0.123 (0.101) | 0.105 (0.099) |
| IL-6 (positive vs negative) | ||||||
| HR | 4.17 (+0.05) | 3.58 (+0.06) | 2.59 (+0.03) | 2.68 (+0.01) | 2.95 (+0.22) | 2.20 (+0.04) |
| 95% CI | 1.97–8.83 | 1.81–7.07 | 1.35–4.99 | 1.33–5.41 | 1.32–6.59 | 0.80–6.01 |
| P-value | <0.001 (0.001) | <0.001 (0.001) | 0.004 (0.006) | 0.006 (0.009) | 0.008 (0.006) | 0.125 (0.105) |
| IL-6R (positive vs negative) | ||||||
| HR | 2.69 (+0.13) | 2.15 (+0.06) | 2.05 (+0.13) | 2.02 (+0.17) | 2.27 (+0.21) | 1.71 (+0.29) |
| 95% CI | 1.27–5.69 | 1.11–4.18 | 1.06–3.99 | 1.01–4.07 | 0.98–5.27 | 0.63–4.66 |
| P-value | 0.010 (0.007) | 0.024 (0.025) | 0.033 (0.039) | 0.047 (0.066) | 0.057 (0.044) | 0.294 (0.289) |
Abbreviations: CCSS=conditional cancer-specific survival; CI=confidence interval; HR=hazard ratio; IL=interleukin; IL-6R=interleukin-6 receptor; MVI=microvascular invasion.
The reduced multivariable models were calculated on the basis of the adjusted survival function for age and gender by each elapsed time point, and were restricted in the variables that considered significant in the full model to be controlled for covariate influence. Bootstrapping with 1000 resamples of the same size of each time point was used.
a
Bootstrapped bias of HR is enclosed within parentheses after raw HR value, and bootstrapped P-value for each variable at moment is enclosed within parentheses after raw P-value. Bootstrapped CIs are not shown here.