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. 2015 Oct 20;290(49):29202–29216. doi: 10.1074/jbc.M115.698597

FIGURE 5.

FIGURE 5.

Phenotype of CAII−/− CAIV−/− offspring. A, adult CAII−/− CAIV−/− mice show a significant reduction in body and testis weight in comparison with WT mice (n = 4). The asterisks refer to the values for animal and testis weight of the bar for WT. **, p ≤ 0.01. B, no change is detectable in the steady-state pHi of isolated sperm from WT and double knockout animals (n ≥ 12). C, cross-sections through WT (top) and CAII−/− CAIV−/− (bottom) testis indicate a thinner germ epithelium in double knockout testis. Representative sections are shown. D, the analysis of 130 tubules of three different WT and double knockout testes displays a reduction of 20% of the germ cell epithelium in CAII−/− CAIV−/− mice.