FIGURE 1.
Neurodegeneration phenotypes induced by P. aeruginosa infection. A, summary of the morphological changes observed in animals infected with P. aeruginosa. B, images of ASE neurons of strain OH4168 and the ASER neuron of strain OH3192 exposed to control E. coli or P. aeruginosa. C, images of the AWC neuron of strain CX5974 exposed to control E. coli or P. aeruginosa. Different morphological changes in the neurons are indicated by white arrows. A–C, synchronized L4 nematodes were cultured on plates containing full lawns of P. aeruginosa for 30 h at 25 °C and then visualized using a Leica M165 FC stereomicroscope. Scale bars, 50 μm. D, chemotaxis of L4 nematodes exposed to E. coli or P. aeruginosa. Asterisks indicate statistical significance (**, p < 0.01). The data represent the results of three independent experiments. Bars, mean ± S.E. (error bars).