FIGURE 4.

Isolation of mutants that are resistant to P. aeruginosa-mediated killing and P. aeruginosa-induced neurodegeneration. A–E, survival curves of mutagenized OH3192 strains exposed to P. aeruginosa. Young adult animals were used, and three replicates were analyzed in each experiment. F, neurodegeneration rates in young adult mutants cultured on full lawn plates of P. aeruginosa for 30 h at 25 °C. Asterisks indicate significant differences (*, p < 0.05; **, p < 0.01). The data represent the results of three independent experiments (n = 60 ± 5 animals). Bars, mean ± S.E. (error bars).