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Occupancy of the secondary allosteric site by dNTP induces the formation of a tight SAMHD1 tetramerization. Shown is the superposition of subunit A (magenta) and subunit C (yellow) from our structure on the subunits from the tetramer structure 4QFX (gray). Subunit C moves toward the core of the tetramer (∼20°) in 4QFX when subunit A is fixed, enabling closer tetramer formation. Bottom, schematic graphic of the conformational change, in the same color scheme.
