Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 20;290(49):29461–29477. doi: 10.1074/jbc.M115.670794

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 9. — Schematic representation of the conformational changes in the hSmc2–4 hinge with middle coiled coils and its interaction with 30-mer ssDNA, based on this study. a, proposed model of the hSMC2h-scc/hSMC4h-scc heterodimer in solution, wherein the coiled coils of both subunits interact with each other. a′, crystal structure of hSmc2H-CC30/hSmc4H-CC30. A cartoon model of hSmc2H-CC30/hSmc4H-CC30 is presented in the right panel. a″, hypothetical V-shaped structure of hSmc2H-CC30/hSmc4H-CC30, in which a total of six basic residues, located in the basic patches, are designated by red circles. b, the initial encounter complex of hSmc2H-CC30/hSmc4H-CC30 and 30-mer ssDNA. c, the most stable complex of hSmc2H-CC30/hSmc4H-CC30 with ssDNA formed via a binding mechanism called “hooking.”