TABLE 8.
Tumor-to-non-tumor uptake ratios of 131I-labeled 8H9 antibodies in LAN-1-xenografted mice
Organ | Tumor-to-non-tumor ratio |
|||||||
---|---|---|---|---|---|---|---|---|
m8H9 (n = 5) |
ch8H9 (n = 5) |
ch8H9-6m (n = 4) |
hu8H9-6m (n = 4) |
|||||
Average | S.E. | Average | S.E. | Average | S.E. | Average | S.E. | |
Tumor | 1.00 | 0.00 | 1.00 | 0.00 | 1.00 | 0.00 | 1.00 | 0.00 |
Heart | 2.67 | 0.31 | 2.09 | 0.28 | 4.09 | 1.62 | 4.98 | 0.66 |
Lungs | 2.52 | 0.43 | 1.64 | 0.22 | 2.79 | 0.98 | 3.46 | 0.58 |
Liver | 2.90 | 0.32 | 2.29 | 0.41 | 3.39 | 1.24 | 4.30 | 0.69 |
Spleen | 5.18 | 0.74 | 4.03 | 0.67 | 6.96 | 2.75 | 6.67 | 0.54 |
Stomach | 6.40 | 1.98 | 5.77 | 0.71 | 7.89 | 1.99 | 11.05 | 1.59 |
Small intestine | 7.29 | 0.63 | 7.11 | 1.05 | 13.03 | 5.04 | 20.50 | 3.13 |
Large intestine | 22.37 | 8.90 | 14.50 | 2.23 | 22.75 | 6.29 | 32.86 | 3.47 |
Kidney | 3.02 | 0.38 | 2.64 | 0.54 | 4.53 | 1.49 | 5.64 | 0.47 |
Adrenal gland | 3.31 | 0.33 | 2.92 | 0.75 | 3.88 | 0.74 | 3.94 | 0.37 |
Skin | 2.31 | 0.24 | 1.73 | 0.26 | 2.92 | 0.76 | 4.42 | 0.55 |
Femur | 5.04 | 0.48 | 5.12 | 1.06 | 7.96 | 1.63 | 7.96 | 1.31 |
Muscle | 7.46 | 0.58 | 7.00 | 0.72 | 8.27 | 2.93 | 15.17 | 3.74 |
Spine | 6.04 | 0.61 | 5.49 | 0.82 | 7.01 | 1.67 | 10.54 | 0.87 |
Brain | 32.65 | 6.03 | 30.60 | 6.62 | 47.54 | 12.77 | 63.35 | 10.18 |
Tail | 3.80 | 0.49 | 3.67 | 0.47 | 4.74 | 1.35 | 6.77 | 0.59 |
Blood | 0.85 | 0.06 | 0.72 | 0.10 | 1.32 | 0.46 | 1.26 | 0.16 |