TABLE 3.

Average (± S.D.) PK parameters following single i.v. or s.c. dose administration at 10 mg/kg in cynos

The following abbreviations are used: t½_β = terminal half-life; CL = non-specific clearance; AUC = area under the concentration time curve from time 0 to time of last measurable concentration; V1 = volume of distribution of the central compartment; %F = bioavailability; k_a = absorption rate constant; t_max = time to maximum serum concentration; C_max = maximum serum concentration; i.v. = intravenous; s.c. = subcutaneous.

Parameter	Anti-LTαparental	Anti-LTα+3	Anti-LTα−4	HumAb4D5-8 parental	HumAb4D5-8 +5	HumAb4D5-8 −4
t½β day	4.62 ± 1.09	3.23 ± 0.766	7.33 ± 0.846	7.06 ± 0.917	8.50 ± 0.372	7.57 ± 2.05
CL ml/day/kg	14.9 ± 2.53	59.3 ± 7.51	5.78 ± 0.415	6.22 ± 0.607	51.1 ± 5.42	6.63 ± 0.559
AUC (i.v.) day·μg/ml	671 ± 114	169 ± 21.4	1730 ± 124	1610 ± 157	196 ± 20.8	1510 ± 127
V1 ml/kg	88.1 ± 18.0	69.7 ± 14.4	50.4 ± 4.57	58.7 ± 7.39	97.3 ± 20.9	66.3 ± 7.33
%F	59.9 ± 14.3	31.4 ± 5.23	69.9 ± 7.62	71.5 ± 10.2	82.7 ± 11.9	117 ± 14.5
ka 1/day	0.970 ± 0.370	0.921 ± 0.213	1.09 ± 0.204	0.555 ± 0.126	0.384 ± 0.0916	0.454 ± 0.0869
tmax (s.c.) day	1.00 ± 0	0.833 ± 0.333	2.50 ± 1.00	3.00 ± 0	1.50 ± 1.00	2.5 ± 1.00
Cmax (s.c.) μg/ml	55.3 ± 17.8	17.0 ± 10.4	143 ± 5.52	88.0 ± 9.25	16.2 ± 4.78	118 ± 20.5