TABLE 1.
List of eIF5A-regulated proteins implicated in PDAC
Proteins implicated in PDAC malignancy in PubMed were manually picked from the list of proteins down-regulated by eIF5A knockdown.
Official symbol | Official full name |
---|---|
ALDH1A2 | Aldehyde dehydrogenase 1 family, member A2 |
ARHGAP5 | Rho GTPase-activating protein 5 |
ATG7 | Autophagy related 7 |
BIRC6 | Baculoviral IAP repeat-containing protein 6 |
CASP8 | Caspase-8 |
CHD3 | Chromodomain helicase DNA binding protein 3 |
CMPK1 | Cytidine monophosphate (UMP-CMP) kinase 1, cytosolic |
CTBP2 | C-terminal-binding protein 2 |
ECH1 | Enoyl-CoA hydratase 1, peroxisomal |
EPHX1 | Epoxide hydrolase 1 |
EPPK1 | Epiplakin |
GALNT3 | Polypeptide N-acetylgalactosaminyltransferase 3 |
GCLC | Glutamate-cysteine ligase catalytic subunit |
GRB7 | Growth factor receptor-bound protein 7 |
HDAC1 | Histone deacetylase 1 |
HUWE1 | HECT, UBA, and WWE domain containing 1 |
IDH2 | Isocitrate dehydrogenase [NADP], mitochondrial |
MUC5AC | Mucin-5AC, oligomeric mucus/gel-forming |
PRKDC | DNA-dependent protein kinase catalytic subunit |
PSMB4 | Proteasome subunit beta type-4 |
RHOA | Ras homolog gene family A |
RHOC | Ras homolog gene family C |
ROCK1 | Rho-associated protein kinase 1 |
ROCK2 | Rho-associated protein kinase 2 |
SDC1 | Syndecan-1 |
SIN3A | SIN3 transcription regulator family member A |
SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase |
TJP1 | Tight junction protein 1 |
TP53BP1 | Tumor protein p53-binding protein 1 |
TRIM29 | Tripartite motif-containing protein 29 |
TRIP10 | Thyroid hormone receptor interactor 10 |
TRRAP | Transformation/transcription domain-associated protein |