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. Author manuscript; available in PMC: 2016 Jul 1.

Published in final edited form as: Alcohol Clin Exp Res. 2015 Jun 3;39(7):1137–1147. doi: 10.1111/acer.12751

Manhattan plot and QQ plot in European Americans (EA) in the Yale-UPenn sample. The peak SNP was rs1229984 (ADH1B) on chromosome 4 (p=5.96 x 10-15). Two novel loci were rs1799876 on chromosome 1 (p=4.00 x 10-8) and rs2309169 on chromosome 2 (5.58 x 10-9). After adjusting for rs122984 on ADH1B, rs2309169 remained significant (p=2.1 x 10-9), but rs1799876 was nearly significant (p=1.99 x 10-7).

Manhattan plot and QQ plot in European Americans (EA) in the Yale-UPenn sample. The peak SNP was rs1229984 (ADH1B) on chromosome 4 (p=5.96 x 10-15). Two novel loci were rs1799876 on chromosome 1 (p=4.00 x 10-8) and rs2309169 on chromosome 2 (5.58 x 10-9). After adjusting for rs122984 on ADH1B, rs2309169 remained significant (p=2.1 x 10-9), but rs1799876 was nearly significant (p=1.99 x 10-7).