. Author manuscript; available in PMC: 2016 Jul 1.

Published in final edited form as: Alcohol Clin Exp Res. 2015 Jun 3;39(7):1137–1147. doi: 10.1111/acer.12751

Table 2. Summary of significant results associated with Maxdrinks in European Americans and African Americans.

European Americans
Chr	BP	a1	a2	SNP	SNP Type	Gene	Yale-UPenn p	Yale-Upenn Beta	SAGE p	SAGE Beta	Meta p	Meta beta	MAF
1	173878471	G	A	rs1799876	INT	SERPINC1	4.00E-08	-0.161	2.62E-02	-0.0522	1.32E-07	-0.08	0.38
2	98239537	A	C	rs2309169	^a	^a	5.58E-09	-0.276	^a	^a	^a	^a	0.1
4	100025015	T	C	rs28470942	INT	LOC100507053	^a	^a	^a	^a	^a	^a	^a
4	100163386	CT	C	rs33948359	INT	LOC100507053	^a	^a	^a	^a	^a	^a	^a
4	100177417	C	A	rs28600890	INT	LOC100507053	^a	^a	^a	^a	^a	^a	^a
4	100190805	T	C	rs28864441	INT	LOC100507053	^a	^a	^a	^a	^a	^a	^a
4	100214164	A	G	rs904092	INT	LOC100507053	9.29E-01	-0.00306	2.26E-02	0.0674	2.67E-01	0.02	0.17
4	100229017	A	G	rs2066702	NSM,REF	ADH1B	.	^a	^a	^a	^a	^a	^a
4	100235053	A	G	rs1789882	REF,SYN	ADH1B	9.97E-01	-0.00014	2.68E-02	0.0652	2.42E-01	0.02	0.17
4	100236762	C	T	rs1693457	INT	ADH1B	9.37E-01	-0.00268	2.19E-02	0.067	2.55E-01	0.02	0.18
4	100239319	A	G	rs1229984	NSM,REF	ADH1B	1.09E-09	-0.335	1.82E-04	-0.222	5.96E-15	-0.26	0.06
4	100261524	C	T	rs34009511	INT	ADH1C	^a	^a	^a	^a	^a	^a	^a
4	177782899	A	AAAAC	rs200475889	^a	^a	^a	^a	^a	^a	^a	^a	^a

African Americans
Chr	BP	a1	a2	SNP	SNP Type	Gene	Yale-Upenn p	Yale-Upenn Beta	SAGE p	SAGE Beta	Meta p	Meta beta	MAF
1	173878471	G	A	rs1799876	INT	SERPINC1	6.02E-01	-0.0162	2.31E-01	0.06	6.27E-01	-0.01
2	98239537	A	C	rs2309169	^a	^a	^a	^a	^a	^a	^a	^a	^a
4	100025015	T	C	rs28470942	INT	LOC100507053	7.67E-06	-0.142	1.67E-03	-0.19	4.23E-08	-0.15	0.18
4	100163386	CT	C	rs33948359	INT	LOC100507053	2.55E-06	-0.145	1.25E-03	-0.19	1.04E-08	-0.15	0.18
4	100177417	C	A	rs28600890	INT	LOC100507053	1.71E-06	-0.147	9.03E-04	-0.19	5.22E-09	-0.16	0.19
4	100190805	T	C	rs28864441	INT	LOC100507053	1.24E-06	-0.149	9.03E-04	-0.19	3.68E-09	-0.16	0.18
4	100214164	A	G	rs904092	INT	LOC100507053	1.85E-05	-0.122	8.75E-03	-0.14	1.45E-08	-0.13	0.24
4	100229017	A	G	rs2066702	NSM,REF	ADH1B	4.93E-07	-0.154	9.82E-04	-0.19	2.50E-10	-0.16	0.19
4	100235053	A	G	rs1789882	REF,SYN	ADH1B	5.06E-06	-0.13	5.33E-03	-0.15	2.10E-09	-0.14	0.23
4	100236762	C	T	rs1693457	INT	ADH1B	7.05E-06	-0.128	8.41E-03	-0.15	4.24E-09	-0.14	0.23
4	100239319	A	G	rs1229984	NSM,REF	ADH1B	^a	^a	^a	^a	^a	^a	^a
4	100261524	C	T	rs34009511	INT	ADH1C	1.38E-06	-0.21	2.43E-02	-0.18	8.11E-08	-0.2	0.09
4	177782899	A	AAAAC	rs200475889	^a	^a	5.32E-08	-0.235	^a	^a	^a	^a	^a

All
Chr	BP	a1	a2	SNP	SNP Type	Gene	Meta p	Meta beta
1	173878471	G	A	rs1799876	INT	SERPINC1	3.17E-06	-0.06
2	98239537	A	C	rs2309169	^a	^a	^a	^a
4	100025015	T	C	rs28470942	INT	LOC100507053	4.23E-08	-0.15
4	100163386	CT	C	rs33948359	INT	LOC100507053	1.04E-08	-0.15
4	100177417	C	A	rs28600890	INT	LOC100507053	5.22E-09	-0.16
4	100190805	T	C	rs28864441	INT	LOC100507053	3.68E-09	-0.159
4	100214164	A	G	rs904092	INT	LOC100507053	5.02E-03	-0.042
4	100229017	A	G	rs2066702	NSM,REF	ADH1B	2.50E-10	-0.16
4	100235053	A	G	rs1789882	REF,SYN	ADH1B	3.25E-03	-0.04
4	100236762	C	T	rs1693457	INT	ADH1B	4.07E-03	-0.04
4	100239319	A	G	rs1229984	NSM,REF	ADH1B	5.96E-15	-0.26
4	100261524	C	T	rs34009511	INT	ADH1C	8.11E-08	-0.2
4	177782899	A	AAAAC	rs200475889	^a	^a	^a	^a

Abbreviations: Chr: chromosome; BP: base pair; SNP: single nucleotide polymorphism; NA: other; NSM: non-synonymous; SYN: synonymous; INT: intronic; Beta: beta coefficient for Maxdrinks; MAF: Minor allele frequency

Not tested because of low minor allele frequency or poor imputation qualityNot tested because

Note: highlighted as red SNPs were identifed assoications for alcohol dependence in our previous study