Figure 1.

Differential CpG methylation between murine neurons and glia. (A) Global levels of methyl-CpG are substantially higher in neuronal (NeuN⁺) compared with non-neuronal (NeuN⁻) cells in mouse cortex. (Shown are the six samples analyzed by Lister et al. and presented in their Fig. 2C.) (B) Chromosome plots of cell type-specific methylation differences (neuronal minus non-neuronal) reveal a general pattern of neuron-specific hypermethylation punctuated by regions of dramatic glia-specific hypermethylation.