. 2015 Nov 24;25(2):382–388. doi: 10.1093/hmg/ddv465

Table 1.

Genome-wide significant associations observed at the AMH gene locus

	SNP	Distance^a	Format^b	Univariate^c		Joint model^d		GCTA model^e		Variance (%)^f
	SNP	Distance^a	Format^b	Beta^g	P	Beta	P	Beta	P	Variance (%)^f
All	rs4807216	430 bp	C/T/0.14	0.25 (0.03)	1.8E–18	0.33 (0.04)	3.E–20	0.34 (0.04)	2.4E–21	5.60
	rs2385821	129 kb	G/A/0.964	0.16 (0.05)	0.002	0.51 (0.06)	5.E–18	0.53 (0.06)	3.9E–18
	rs8112524	Intronic	G/A/0.39	0.16 (0.02)	6.7E–13	0.08 (0.03)	2.E–03	0.09 (0.03)	0.0004
Males	rs4807216	430 bp	C/T/0.14	0.46 (0.03)	7.4E–50	0.53 (0.04)	2.E–49	0.56 (0.04)	6.0E–45	24.50
	rs2385821	129 kb	G/A/0.964	0.14 (0.06)	0.02	0.7 (0.06)	6.E–31	0.78 (0.07)	1.9E–28
	rs8112524	Intronic	G/A/0.39	0.3 (0.02)	2.0E–34	0.15 (0.03)	3.E–08	0.18 (0.03)	1.3E–09
Females	rs4807216	430 bp	C/T/0.14	0.01 (0.04)	0.67	0.09 (0.05)	7.E–02	0.08 (0.04)	0.06	0.80
	rs2385821	129 kb	G/A/0.964	0.17 (0.06)	0.008	0.25 (0.07)	8.E–04	0.25 (0.07)	0.0009
	rs8112524	Intronic	G/A/0.39	0.01 (0.03)	0.81	0.002 (0.03)	9.E–01	−0.001 (0.03)	0.97

^aDistance from AMH protein-coding gene.

^bEffect allele/other allele/effect allele frequency.

^cUnadjusted test statistics from the primary genome-wide association scan.

^dEffect estimates when all three SNPs are jointly included in the regression model.

^eEffect estimates when all three SNPs are jointly included in the GCTA approximate conditional analysis framework.

^fTrait variance explained by all three SNPs.

^gAll effect estimates based on natural log-transformed ng/ml serum AMH.