Table 2.
Blood biochemical characteristics of the AFP-negative HCC patients
| Patient | ALT | AST | GGT | ADA | TBA | TBIL | PT | Test for hepatitis B |
|---|---|---|---|---|---|---|---|---|
| 1 | 40.1 | 20.0 | 64.7↑ | 12.8 | 5.3 | 10.7 | 10.9 | (−) |
| 2 | 46.5 | 43.7↑ | 69.4↑ | 42.5↑ | 47.7↑ | 7.9 | 11.0 | Small three positive |
| 3 | 23.4 | 25.0 | 11.7 | 26.4↑ | 6.4 | 19.3 | 11.4 | Small three positive |
| 4 | 44.5 | 50.1↑ | 106.9↑ | 20.7 | 44.4↑ | 13.8 | 11.7 | Small three positive |
| 5 | 63.3↑ | 54.9↑ | 83.9↑ | 20.2 | 53.8↑ | 7.5 | 11.0 | Small three positive |
| 6 | 28.6 | 24.5 | 69.5↑ | 13.8 | 2.8 | 8.8 | 10.1 | (−) |
| 7 | 25.0 | 19.5 | 51.8 | 11.0 | 5.1 | 7.8 | 10.3 | Great three positive |
| 8 | 105.8↑ | 72.8↑ | 191.7↑ | 18.7 | 49.4↑ | 28.5↑ | 13.3↑ | Small three positive |
| 9 | 22.0 | 13.5 | 26.6 | 20.5 | 2.0 | 20.5 | 12.3↑ | Small three positive |
| 10 | 374.2↑ | 458.8↑ | 95.6↑ | 25.0 | 11.7 | 18.4 | 12.0 | Great three positive |
| 11 | 14.2 | 21.6 | 15.0 | 18.6 | 11.8 | 19.2 | 10.8 | (−) |
| 12 | 63.8↑ | 87.6↑ | 19.6 | 18.1 | 16.9↑ | 33.0↑ | 16.6↑ | Small three positive |
| 13 | 65.1↑ | 63.9↑ | 66.3↑ | 29.5↑ | 16.2↑ | 10.4 | 11.2 | Great three positive |
| 14 | 67.0↑ | 47.1↑ | 257.5↑ | 12.6 | 11.5 | 10.0 | 12.0 | Small three positive |
| 15 | 49.0 | 38.0 | 47.0 | 11.8 | 9.7 | 8.6 | 13.5↑ | Small three positive |
| 16 | 15.7 | 23.3 | 10.8 | 8.8 | 1.8 | 7.6 | 9.7↓ | (−) |
| 17 | 20.9 | 44.2↑ | 80.7↑ | 18.2 | 7.6 | 13.1 | 10.7 | (−) |
| 18 | 23.9 | 24.2 | 24.1 | 22.0 | 2.1 | 15.1 | 10.1 | (−) |
| 19 | 13.9 | 17.6 | 16.5 | 1.7 | 2.6 | 4.6↓ | 11.9 | (−) |
| 20 | 41.0 | 47.8↑ | 303.0↑ | 17.3 | 5.2 | 16.6 | 10.6 | (−) |
| 21 | 32.2 | 25.2 | 101 | 20.0 | 10.0 | 21.1 | 10.0 | Small three positive |
| 22 | 14.3 | 46.6↑ | 52.2↑ | 16.9 | 11.9 | 26.0↑ | 11.0 | Great three positive |
| 23 | 41.4↑ | 16.4 | 43.1 | 9.3 | 9.8 | 14.7 | 12.7↑ | Small three positive |
| 24 | 55.9↑ | 28.5 | 16.9 | 14.8 | 15.3 | 16.9 | 14.1↑ | (−) |
| 25 | 60.4↑ | 37.2↑ | 18.8 | 32.0 | 1.8 | 13.0 | 10.1 | Small three positive |
| 26 | 35.7 | 47.3↑ | 32.3 | 10.0 | 5.4 | 18.1 | 8.7↓ | Small three positive |
| 27 | 30.6 | 25.7 | 31.9 | 6.5 | 9.0 | 9.6 | 9.9 | (−) |
| 28 | 28.8 | 35.8↑ | 43.5 | 21.1 | 7.5 | 4.9↓ | 11.5 | Small three positive |
| 29 | 30.2 | 45.9↑ | 54.4↑ | 17.4 | 6.4 | 13.4 | 12.1 | Great three positive |
| 30 | 15.3 | 24.0 | 62.8↑ | 18.8 | 10.6 | 16.8 | 13.7 | Small three positive |
| 31 | 10.7 | 36.4↑ | 43.6 | 13.0 | 4.4 | 18.9 | 10.8 | Small three positive |
| 32 | 15.1 | 16.3 | 41.7 | 12.4 | 6.8 | 19.2 | 9.9 | Small three positive |
| 33 | 34.2 | 56.2↑ | 21.6 | 17.3 | 9.7 | 10.4 | 10.3 | (−) |
| 34 | 39.5 | 46.1↑ | 35.5 | 15.4 | 12.4↑ | 11.1 | 11.9 | (−) |
| 35 | 15.2 | 67.3↑ | 41.1 | 7.5 | 11.6 | 17.6 | 12.5↑ | Small three positive |
| 36 | 28.7 | 43.5↑ | 10.3 | 11.0 | 20.1↑ | 20.3 | 11.0 | Small three positive |
| 37 | 19.3 | 52.4↑ | 39.4 | 3.7 | 7.7 | 21.8 | 9.8 | Small three positive |
| 38 | 20.7 | 16.6 | 28.7 | 9.9 | 6.6 | 25.1↑ | 10.1 | (−) |
| 39 | 21.9 | 18.7 | 68.9↑ | 5.8 | 2.3 | 16.4 | 9.9 | Small three positive |
| 40 | 17.6 | 19.8 | 56.5↑ | 30.0 | 1.4 | 10.9 | 10.1 | Small three positive |
| 41 | 36.4 | 20.9 | 36.3 | 19.8 | 3.1 | 12.4 | 11.4 | (−) |
| 42 | 68.8↑ | 64.9↑ | 41.4 | 12.7 | 1.6 | 16.6 | 12.0 | (−) |
| 43 | 35.0 | 25.6 | 32.6 | 14.6 | 5.7 | 18.8 | 10.5 | (−) |
| 44 | 102.2↑ | 23.4 | 69.5 | 25.0 | 6.6 | 17.0 | 16.1↑ | (−) |
| 45 | 21.3 | 24.5 | 26.9 | 8.9 | 46.1↑ | 16.4 | 8.8↓ | Small three positive |
| 46 | 38.4 | 14.6 | 18.4 | 24.3 | 5.7 | 7.7 | 11.7 | (−) |
| 47 | 25.5 | 16.4 | 27.3 | 16.4 | 4.3 | 3.6↓ | 13.9↑ | Small three positive |
| 48 | 21.7 | 19.3 | 109.1↑ | 30.0↑ | 6.1 | 8.5 | 11.1 | Small three positive |
| 49 | 64.8↑ | 20.8 | 76.0↑ | 18.8 | 7.9 | 16.5 | 10.0 | (−) |
| 50 | 11.9 | 36.7↑ | 58.9↑ | 17.9 | 4.7 | 38.0↑ | 9.9 | Small three positive |
Notes: Reference intervals of serum markers: ALT (7–40 U/L), AST (13–35 U/L), GGT (7–45 U/L), ADA (0–25 U/L), TBA (0–12 µmol/L), TBIL (5–24 µmol/L), PT (9.8–12.1 seconds), FB (1.8–3.5 g/L), APTT (22.7–31.8 seconds), and TT (14–21 seconds). Tests for hepatitis B (HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb): small three positive (HBsAg-positive, HBeAb-positive, and HBcAb-positive); great three positive (HBsAg-positive, HBeAg-positive, and HBcAb-positive). (↑), high level, (↓), low level.
Abbreviations: AFP, alpha-fetoprotein; HCC, hepatocellular carcinoma; HBsAg, hepatitis B surface antigen; HBsAb, hepatitis B surface antibody; HBeAg, hepatitis B e antigen; HBeAb, hepatitis B e antibody; HBcAb, hepatitis B core antibody; FB, fibrinogen; APTT, activated partial thromboplastin time; TT, thrombin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyl transpeptidase; ADA, adenosine deaminase; TBA, total bile acids; TBIL, total bilirubin; PT, prothrombin time.