Table 3.
Comparison of the five brain regions between the physically active and sedentary HIV + groups, in unadjusted and adjusted analyses
| Brain volume, in cc | HIV + PA group (n = 22) | HIV + sedentary (n = 48) | Unadjusted difference PA-sedentary | Adjusted difference PA-sedentary1 | ||
|---|---|---|---|---|---|---|
|
|
|
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| Mean (SD) | Mean (SD) | Mean (95% CI) | p-Value | Mean (95% CI) | p-Value | |
| Total Gray Matter | 608.6 (57.0) | 595.4 (60.0) | 13.2 (−17.2, 43.5) | .39 | 18.8 (−6.9, 44.5) | .15 |
| Total White Matter | 461.4 (60.0) | 446.2 (52.8) | 15.2 (−13.1, 43.5) | .29 | 18.3 (−9.5, 46.0) | .19 |
| Caudate | 7.12 (1.13) | 6.98 (1.25) | 0.14 (−0.48, 0.76) | .66 | 0.35 (−0.24, 0.95) | .24 |
| Putamen | 11.04 (1.48) | 10.52 (1.70) | 0.52 (−0.32, 1.36) | .22 | 0.86 (0.15, 1.57) | .02* |
| Hippocampus | 8.00 (0.93) | 7.69 (0.97) | 0.31 (−0.19, 0.80) | .22 | 0.28 (−0.21, 0.77) | .25 |
Note. Adjusted analyses control for confounders significant at 0.20 level in backward model selection. All brain volumes are normalized for intra-cranial volume. Final adjusted (multivariable) model is controlling for the following covariates. Total gray matter: age, sex, education. Total white matter: age, sex, education. Caudate: age, nadir CD4, log10 viral load. Putamen: age, sex, nadir CD4. Hippocampus: age, education. For all five brain regions, age had a significant negative association with the brain volume.
Statistically significant correlation.
PA, physically active; SD, standard deviation; CI, confidence interval