Table 2.

Haplotype analysis at the 17q25.3 locus

Locus	Haplotype	Frequency	Frequency FTD case	Frequency controls	OR (95% CI)	p Value
rs906175, rs2659030, rs9912789, rs9896850, rs2725391, rs9319617, rs12939525, rs8073077, rs969413, rs1048775, rs2255166, rs2659005	(1) CGTTCCCTTGTC	0.43	0.39	0.49	0.695 (0.59–0.82)	7.42 × 10−6
(2) TACCTTTCACCT	0.43	0.52	0.42	1.42 (1.20–1.65)	1.60 × 10−5
(3) CGCCCCTCTGTC	0.02	0.02	0.03	0.71 (0.41–1.23)	21.7 × 10−1
(4) TACCTTTCACCC	0.02	0.03	0.02	1.35 (0.79–2.31)	2.92 × 10−1
(5) TACCTTTCACTT	0.02	0.02	0.02	1.31 (0.71–2.40)	3.83 × 10−1
(6) CGCCCTTCTGTC	0.02	0.03	0.02	1.005 (0.77–1.32)	9.73 × 10−2
rs906175,rs2659030, rs2725391, rs969413, rs1048775, rs9319617, rs2255166	(1) CGCTGCT	0.47	0.42	0.52	0.67 (0.58–0.79)	8.30 × 10−7
(2) TATACTC	0.45	0.53	0.43	1.45 (1.23–1.69)	4.39 × 10−6
(3) CGCACCC	0.01	0.01	0.01	0.56 (0.25–1.24)	1.50 × 10−1
(4) TATACTT	0.02	0.02	0.02	1.37 (0.77–2.40)	2.86 × 10−1
(5) CGCTGTT	0.02	0.02	0.02	0.92 (0.55–1.55)	7.56 × 10−1

Logistic regression results for haplotypes constructed using 12 and 7 SNPs mapping to the long arm of chr 17 (17q25.3 locus), adjusting for sex and the first 4 principal components. For each haplotype, we reported the frequency in FTD cases and controls.

Key: CI, confidence interval; FTD, frontotemporal dementia; OR, odds ratio; SNPs, single nucleotide polymorphisms.