Table 3.
Gender stratified analysis
| SNP | p-Value females | OR (CI 95%) females | p-Value males | OR (CI 95%) males | p-Value int | OR (CI 95%) int | Coded allele | Gene | Function |
|---|---|---|---|---|---|---|---|---|---|
| rs3110642 | 3.11 × 10−6 | 2.15 (1.56–2.96) | 5.80 × 10−2 | 1.32 (0.99–1.76) | 0.022 | 1.62 (1.08–2.53) | C | HNF1B | Intron |
| rs3110643 | 4.55 × 10−6 | 2.12 (1.54–2.92) | 5.24 × 10−2 | 1.33 (0.997–1.78) | 0.027 | 1.59 (1.05–2.50) | C | HNF1B | Intron |
| rs3110648 | 1.51 × 10−5 | 1.96 (1.44–2.65) | 2.18 × 10−2 | 1.38 (1.05–1.82) | 0.077 | 1.42 (0.96–2.17) | G | HNF1B | Intron |
| rs9912789 | 2.25 × 10−5 | 0.61 (0.48–0.77) | 8.02 × 10−3 | 0.74 (0.59–0.92) | 0.259 | 0.83 (0.60–1.15) | T | CEP131 | Intron |
| rs2659030 | 3.41 × 10−5 | 1.61 (1.29–2.02) | 2.76 × 10−3 | 1.41 (1.13–1.78) | 0.451 | 1.14 (0.82–1.54) | A | CEP131 | Intron |
| rs906175 | 3.43 × 10−5 | 1.61 (1.29–2.02) | 3.96 × 10−4 | 1.51 (1.20–1.89) | 0.728 | 1.07 (0.77–1.45) | T | CEP131 | Intron |
| rs9319617 | 4.16 × 10−5 | 0.62 (0.50–0.78) | 1.80 × 10−3 | 0.70 (0.56–0.89) | 0.501 | 0.89 (0.65–1.23) | C | CEP131 | Intron |
| rs9896850 | 7.56 × 10−5 | 0.63 (0.50–0.79) | 2.36 × 10−3 | 0.70 (0.56–0.88) | 0.519 | 0.89 (0.65–1.24) | T | CEP131 | Intron |
We reported the logistic regression results for females (n = 637) and for males (n = 821) and the gender × SNP interaction analysis for the total sample (n = 1458) with odds ratio (OR) = OR (female)/OR (male). For each SNP, we reported the coded allele associated to odds ratio and the relative mapped gene and function.
Key: CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism.