Table 4.
Case and/or control MAPT haplotype association analysis
| MAPT haplotypea | FTD (n = 516) | Controls (n = 909) | OR (95% CI) | p Value |
|---|---|---|---|---|
| H1/H1 | 302 (58.5%) | 503 (55.3%) | 1.20 (0.96–1.51) | 0.107 |
| H1/H2 | 194 (37.1%) | 349 (38.4%) | 0.93 (0.74–1.18) | 0.566 |
| H2/H2 | 29 (3.90%) | 57 (6.30%) | 0.54 (0.32–0.92) | 0.025 |
For each MAPT haplotype, we reported the frequencies (numbers and %) in FTD cases and controls. In both analyses, the logistic regressions are corrected for sex and the first 4 principal components.
Key: CI, confidence interval; FTD, frontotemporal dementia, MAPT, microtubule-associated protein tau.
a
Sixteen cases and 17 controls had missing values.