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. 2015 Jan;36(1):334–343. doi: 10.1016/j.neurobiolaging.2014.07.007

Fig. 4.

Fig. 4

Aged 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1−/−) mice maintain low intrahippocampal corticosterone (CORT) levels and intact spatial memory despite tail-nick stress before retrieval. (A) Plasma CORT levels after tail-nick stress and its effect on intrahippocampal CORT dynamics (in consecutive 10-minute dialysate samples, *** p < 0.001, ** p < 0.01, * p < 0.05 vs. equivalent time point in 11β-HSD1−/− mice) during Y-maze performance (B) and resulting spatial memory retention after a 2-hour intertrial interval (ITI) (# p < 0.05 vs. start and other arms) (C) in aged 24- to 26-month-old wild-type (WT) (n = 5) and 11β-HSD1−/− mice (n = 6).