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. Author manuscript; available in PMC: 2016 Oct 5.
Published in final edited form as: J Toxicol Environ Health A. 2015 Oct 5;78(19):1201–1216. doi: 10.1080/15287394.2015.1075165

Figure 7. Age effects on the systemic bone deterioration response to repetitive ODE inhalation exposure by micro-CT analysis.

Figure 7

Young (7–9 week) and older (12–14 month) C57BL/6 mice were i.n. treated daily with saline or ODE for 3 weeks whereupon trabecular bone of proximal tibia was subjected to micro-CT analysis. Changes in bone quality and bone quantity were consistently observed in ODE-treated young mice as compared to saline. Age alone significantly affected bone measurements in older mice. Bar graphs are means with standard deviation (N=5 mice/group). Asterisks denote statistical significance (*p<0.05) vs. young saline treated mice. Lines between groups denotes statistical significance (#p<0.05).