Table II.

Physiological and Kinetic Parameters for Gefitinib PBPK Simulations in Humans

Organ	Human (70 kg)
	Organ volume (L)a	Blood flow rate (L/h)a
Spleen	0.19	3.39
Liver	1.80	76.3
Fat	11.6	26.2
Eye	0.01	0.09
Muscle	28.0	64.2
Kidney	0.31	58.8
Heart	0.33	13.4
Lung	0.53	336
Skin	2.60	20.2
Brain	1.40	40.3
Gut	1.19	60.8
Venous	5.60	336
Remainder	16.7	33.2

^aThe blood flow rate and organ volume in each tissue were obtained based on a 70-kg man from literature data (34)