Table IV.

Gefitinib Pharmacokinetic Parameters for Mice in Plasma and Various Tissues Calculated Based on the Experimental Data and PBPK Predictions Using the Noncompartmental Analysis

Parameters	Unit	NCA estimated	PBPK estimated	Diff%
C max	μg/mL	4.46	3.70	17.0
t 1/2	h	2.72	2.90	6.62
C max − liver	μg/mL	52.5	61.8	17.7
t 1/2liver	h	19.3	16.4	15.0
AUCplasma 0 − 24	h*μg/mL	7.87	9.50	20.7
AUClung 0 − 24	h*μg/mL	165	161	2.48
AUCspleen 0 − 24	h*μg/mL	81.3	101	24.1
AUCgut 0 − 24	h*μg/mL	74.7	93.7	25.4
AUCliver 0 − 24	h*μg/mL	123	140	14.5
AUCkidney 0 − 24	h*μg/mL	68.4	66.2	3.22
AUCbrain 0 − 24	h*μg/mL	5.80	6.62	14.1
AUCeye 0 − 24	h*μg/mL	11.1	10.3	7.21
AUCheart 0 − 24	h*μg/mL	24.1	22.8	5.40
AUCmuscle 0 − 24	h*μg/mL	14.0	14.0	0
AUCfat 0 − 24	h*μg/mL	16.0	14.8	7.50

NCA noncompartmental analysis, PBPK physiologically based pharmacokinetic, Diff% percentage of difference, AUC area under the curve