Fig. 5.

Timeline of medication ages relative to their expiration dates. All medications were aged on the ISS for 550 Earth days. Assays were performed after sample return to Earth at the time points indicated above, relative to their original manufacturer expiration date (shown in bold). Most (white boxes) passed 2012 USP requirements for amount of active pharmaceutical ingredient (API) and for degradants/impurities. Melatonin (shaded box) failed both API and degradants/impurities assays. Note that the acetaminophen, loratadine, and loperamide samples would fail according to updated USP guidelines