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Analysis of testis defects in RHOX8-KD mice. Caudal sperm counts (A) and motility (B) were determined in control (n = 16) and RHOX8-KD (n = 45) mice. C) RHOX8-KD mice exhibited an increased proportion of TUNEL-positive testis tubules and apoptotic cells per TUNEL-positive tubule compared to control animals. At least six animals and 800 tubule cross sections were counted per genotype for each time point. *P < 0.01, **P < 0.001.
