Table 3. Effect of N-acetylthioureas on KDAC8 Activity with Fluor-de-Lys substrate in assay buffer 2 in the presence of excess zinc.

	Activity (pmol min-1 μg-1)
Concentration of zinc (fold excess)	No N-acetylthiourea	10 μmol L-1 TM-2-51	10 μmol L-1 TM-2-88	10 μmol L-1 TM-2-104
0 nmol L-1 (0X)	18.2 ± 3.4	21.9 ± 4.3	21.0 ± 2.4	17.8 ± 2.7
200 nmol L-1 (1X)	18.5 ± 1.1	19.7 ± 2.1	18.2 ± 0.9	18.1 ± 0.3
400 nmol L-1 (2X)	17.6 ± 1.9	21.7 ± 4.0	19.4 ± 1.7	20.1 ± 4.4