Fig 4. Histopathological findings of liver tissues from young mice fed normal chow or high-fat/high-sucrose diet.

Liver specimens were obtained from male wild type (A and C) or Tet-mev-1 mice (B and D) that had been supplied with doxycycline-containing water throughout the prenatal and postnatal periods and, at around the age of 1 year, were subsequently fed a control, normal diet (A and B) or high-fat/high-sucrose diet (C and D) for 4 months. Serial sections were subjected to hematoxylin and eosin staining (upper) or Sirius red-Fast green FCF staining (lower). Representative images from eight mice in each group are shown. Scale bars, 100 μm.