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. 2004 Aug;72(8):4924–4928. doi: 10.1128/IAI.72.8.4924-4928.2004

FIG. 3.

FIG. 3.

Clinical outcome (A) and IFN-γ (B) responses following L. major challenge in mice vaccinated with DNA-Salmonella primer-booster (LACK-DNA/LACK-Sal) regimen compared to those for mice vaccinated with DNA alone (LACK-DNA/Vec-Sal) (n = 10 mice/group). Responses for mice vaccinated with LACK-DNA/Vec-Sal did not differ significantly from those for mice vaccinated with Vec-DNA/Vec-Sal (data not shown). Clinical outcome was measured as footpad depth following injection of L. major into the hind footpad. Asterisks indicate significance at P = 0.001 over the course of infection determined by using Hotelling's T-squared generalized means test. IFN-γ levels were measured in supernatants from pooled spleen cells (n = 3 mice/group) restimulated in vitro with the use of infected DC. Student's t tests demonstrated differences at P < 0.001 for LACK-DNA/LACK-Sal versus LACK-DNA/Vec-Sal and P < 0.05 for LACK-DNA/Vec-Sal versus Vec-DNA/Vec-Sal.