Table 3.
Univariate and multivariate analysis for clinical and radiographic predictors of local control for all patients
| Clinical |
Radiographic |
|||||
|---|---|---|---|---|---|---|
| Univariate |
Multivariate |
Univariate |
Multivariate |
|||
| Variable | P value | HR (95% CI) | P value | P value | HR (95% CI) | P value |
| BED (≥80 Gy) | .01 | 0.204 (0.043-0.963) | .049 | <.001 | 0.075 (0.013-0.430) | .004 |
| GTV (cm3) | .378 | 1.006 (0.998-1.014) | .155 | .203 | 1.008 (0.999-1.017) | .103 |
| Gender | .291 | - | - | .325 | - | - |
| Age | .417 | - | - | .258 | - | - |
| >5 metastatic lesions treated | .245 | - | - | .280 | - | - |
| Location of lesion | .143 | - | - | .169 | - | - |
| Total dose | .911 | - | - | .060 | - | - |
| Dose per fraction (≥9 Gy) | .042 | 1.007 (0.830-1.222) | .946 | .014 | 1.047 (0.871-1.258) | .627 |
| Smoking history | .385 | 1.323 (0.420-4.209) | .637 | .067 | 1.042 (0.298-3.639) | .949 |
| Systemic therapy before radiation | .438 | - | - | .250 | - | - |
| Systemic therapy after radiation | .934 | 0.891 (0.281-2.827) | .846 | .169 | 0.542 (0.169-1.742) | .306 |
BED, biologic effective dose; CI, confidence interval; GTV, gross tumor volume; HR, hazard ratio.