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. Author manuscript; available in PMC: 2016 Jul 15.
Published in final edited form as: Mol Cell Endocrinol. 2015 Mar 14;410:64–72. doi: 10.1016/j.mce.2015.03.001

Figure 2. Caloric Restriction and Leptin Alters Soluble Leptin Receptor and BMP-2 Levels.

Figure 2

(A) ELISA analysis showed circulating levels of soluble leptin receptor (sLR) in the BM interstitial fluid decrease with age and this was reversed with nutrient restriction, but sLR were reduced in response to addition of exogenous leptin. (B) BMP-2 levels in BM interstitial fluid normalized to protein. ELISA analysis showed circulating levels of BMP-2 were highest in mice on CR treated with leptin. Data are shown as means ± S.E.M, n=6.